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DOK7 Gene Therapy Enhances Neuromuscular Junction Innervation and Motor Function in Aged Mice

Muscle denervation at the neuromuscular junction (NMJ), the essential synapse between motor neuron and skeletal muscle, is associated with age-related motor impairment. Therefore, improving muscle innervation at aged NMJs may be an effective therapeutic strategy for treating the impairment. We previ...

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Publicat a:iScience
Autors principals: Ueta, Ryo, Sugita, Satoshi, Minegishi, Yoshihiko, Shimotoyodome, Akira, Ota, Noriyasu, Ogiso, Noboru, Eguchi, Takahiro, Yamanashi, Yuji
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2020
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7452162/
https://ncbi.nlm.nih.gov/pubmed/32758427
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2020.101385
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