DOK7 Gene Therapy Enhances Neuromuscular Junction Innervation and Motor Function in Aged Mice

Muscle denervation at the neuromuscular junction (NMJ), the essential synapse between motor neuron and skeletal muscle, is associated with age-related motor impairment. Therefore, improving muscle innervation at aged NMJs may be an effective therapeutic strategy for treating the impairment. We previ...

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Pubblicato in:iScience
Autori principali: Ueta, Ryo, Sugita, Satoshi, Minegishi, Yoshihiko, Shimotoyodome, Akira, Ota, Noriyasu, Ogiso, Noboru, Eguchi, Takahiro, Yamanashi, Yuji
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7452162/
https://ncbi.nlm.nih.gov/pubmed/32758427
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2020.101385
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