Lactate Dehydrogenase A Depletion Alters MyC-CaP Tumor Metabolism, Microenvironment, and CAR T Cell Therapy

To enhance human prostate-specific membrane antigen (hPSMA)-specific chimeric antigen receptor (CAR) T cell therapy in a hPSMA(+) MyC-CaP tumor model, we studied and imaged the effect of lactate dehydrogenase A (LDH-A) depletion on the tumor microenvironment (TME) and tumor progression. Effective LD...

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Udgivet i:Mol Ther Oncolytics
Main Authors: Mane, Mayuresh M., Cohen, Ivan J., Ackerstaff, Ellen, Shalaby, Khalid, Ijoma, Jenny N., Ko, Myat, Maeda, Masatomo, Albeg, Avi S., Vemuri, Kiranmayi, Satagopan, Jaya, Moroz, Anna, Zurita, Juan, Shenker, Larissa, Shindo, Masahiro, Nickles, Tanner, Nikolov, Ekaterina, Moroz, Maxim A., Koutcher, Jason A., Serganova, Inna, Ponomarev, Vladimir, Blasberg, Ronald G.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Gene & Cell Therapy 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7452096/
https://ncbi.nlm.nih.gov/pubmed/32913888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omto.2020.07.006
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