Lactate Dehydrogenase A Depletion Alters MyC-CaP Tumor Metabolism, Microenvironment, and CAR T Cell Therapy

To enhance human prostate-specific membrane antigen (hPSMA)-specific chimeric antigen receptor (CAR) T cell therapy in a hPSMA(+) MyC-CaP tumor model, we studied and imaged the effect of lactate dehydrogenase A (LDH-A) depletion on the tumor microenvironment (TME) and tumor progression. Effective LD...

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Veröffentlicht in:Mol Ther Oncolytics
Hauptverfasser: Mane, Mayuresh M., Cohen, Ivan J., Ackerstaff, Ellen, Shalaby, Khalid, Ijoma, Jenny N., Ko, Myat, Maeda, Masatomo, Albeg, Avi S., Vemuri, Kiranmayi, Satagopan, Jaya, Moroz, Anna, Zurita, Juan, Shenker, Larissa, Shindo, Masahiro, Nickles, Tanner, Nikolov, Ekaterina, Moroz, Maxim A., Koutcher, Jason A., Serganova, Inna, Ponomarev, Vladimir, Blasberg, Ronald G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Gene & Cell Therapy 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7452096/
https://ncbi.nlm.nih.gov/pubmed/32913888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omto.2020.07.006
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