LDH-A regulates the tumor microenvironment via HIF-signaling and modulates the immune response

Previous studies show that LDH-A knockdown reduces orthotopic 4T1 breast tumor lactate and delays tumor growth and the development of metastases in nude mice. Here, we report significant changes in the tumor microenvironment (TME) and a more robust anti-tumor response in immune competent BALB/c mice...

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Udgivet i:PLoS One
Main Authors: Serganova, Inna, Cohen, Ivan J., Vemuri, Kiranmayi, Shindo, Masahiro, Maeda, Masatomo, Mane, Mayuresh, Moroz, Ekaterina, Khanin, Raya, Satagopan, Jaya, Koutcher, Jason A., Blasberg, Ronald
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2018
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6153000/
https://ncbi.nlm.nih.gov/pubmed/30248111
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0203965
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