Enhancement of PSMA-Directed CAR Adoptive Immunotherapy by PD-1/PD-L1 Blockade

Chimeric antigen receptor (CAR) T cell therapy in hematologic malignancies has shown remarkable responses, but the same level of success has not been observed in solid tumors. A new prostate cancer model (Myc-CaP:PSMA(+)) and a second-generation anti-hPSMA human CAR T cells expressing a Click Beetle...

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Detalhes bibliográficos
Publicado no:Mol Ther Oncolytics
Main Authors: Serganova, Inna, Moroz, Ekaterina, Cohen, Ivan, Moroz, Maxim, Mane, Mayuresh, Zurita, Juan, Shenker, Larissa, Ponomarev, Vladimir, Blasberg, Ronald
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Gene & Cell Therapy 2016
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5363727/
https://ncbi.nlm.nih.gov/pubmed/28345023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omto.2016.11.005
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