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Extent and context dependence of pleiotropy revealed by high-throughput single-cell phenotyping

Pleiotropy—when a single mutation affects multiple traits—is a controversial topic with far-reaching implications. Pleiotropy plays a central role in debates about how complex traits evolve and whether biological systems are modular or are organized such that every gene has the potential to affect m...

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Vydáno v:PLoS Biol
Hlavní autoři: Geiler-Samerotte, Kerry A., Li, Shuang, Lazaris, Charalampos, Taylor, Austin, Ziv, Naomi, Ramjeawan, Chelsea, Paaby, Annalise B., Siegal, Mark L.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2020
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7451985/
https://ncbi.nlm.nih.gov/pubmed/32804946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.3000836
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