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Fitness variation across subtle environmental perturbations reveals local modularity and global pleiotropy of adaptation

Building a genotype-phenotype-fitness map of adaptation is a central goal in evolutionary biology. It is difficult even when adaptive mutations are known because it is hard to enumerate which phenotypes make these mutations adaptive. We address this problem by first quantifying how the fitness of hu...

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Библиографические подробности
Опубликовано в: :eLife
Главные авторы: Kinsler, Grant, Geiler-Samerotte, Kerry, Petrov, Dmitri A
Формат: Artigo
Язык:Inglês
Опубликовано: eLife Sciences Publications, Ltd 2020
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7880691/
https://ncbi.nlm.nih.gov/pubmed/33263280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.61271
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