Muscarinic-dependent phosphorylation of the cardiac ryanodine receptor by protein kinase G is mediated by PI3K–AKT–nNOS signaling

Post-translational modifications of proteins involved in calcium handling in myocytes, such as the cardiac ryanodine receptor (RyR2), critically regulate cardiac contractility. Recent studies have suggested that phosphorylation of RyR2 by protein kinase G (PKG) might contribute to the cardioprotecti...

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Bibliografiska uppgifter
I publikationen:J Biol Chem
Huvudupphovsmän: Baine, Stephen, Thomas, Justin, Bonilla, Ingrid, Ivanova, Marina, Belevych, Andriy, Li, Jiaoni, Veeraraghavan, Rengasayee, Radwanski, Przemyslaw B., Carnes, Cynthia, Gyorke, Sandor
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2020
Ämnen:
Signal Transduction
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7450129/
https://ncbi.nlm.nih.gov/pubmed/32580946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.014054
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