Muscarinic-dependent phosphorylation of the cardiac ryanodine receptor by protein kinase G is mediated by PI3K–AKT–nNOS signaling

Post-translational modifications of proteins involved in calcium handling in myocytes, such as the cardiac ryanodine receptor (RyR2), critically regulate cardiac contractility. Recent studies have suggested that phosphorylation of RyR2 by protein kinase G (PKG) might contribute to the cardioprotecti...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Baine, Stephen, Thomas, Justin, Bonilla, Ingrid, Ivanova, Marina, Belevych, Andriy, Li, Jiaoni, Veeraraghavan, Rengasayee, Radwanski, Przemyslaw B., Carnes, Cynthia, Gyorke, Sandor
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2020
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7450129/
https://ncbi.nlm.nih.gov/pubmed/32580946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.014054
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