Drug-target binding quantitatively predicts optimal antibiotic dose levels in quinolones

Antibiotic resistance is rising and we urgently need to gain a better quantitative understanding of how antibiotics act, which in turn would also speed up the development of new antibiotics. Here, we describe a computational model (COMBAT-COmputational Model of Bacterial Antibiotic Target-binding) t...

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Библиографические подробности
Опубликовано в: :PLoS Comput Biol
Главные авторы: Clarelli, Fabrizio, Palmer, Adam, Singh, Bhupender, Storflor, Merete, Lauksund, Silje, Cohen, Ted, Abel, Sören, Abel zur Wiesch, Pia
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2020
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7449454/
https://ncbi.nlm.nih.gov/pubmed/32797079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1008106
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