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Ethionamide Population Pharmacokinetic Model and Target Attainment in Multidrug-Resistant Tuberculosis

Ethionamide (ETA), an isonicotinic acid derivative, is part of the multidrug-resistant tuberculosis (MDR-TB) regimen. The current guidelines have deprioritized ETA because it is potentially less effective than other agents. Our aim was to develop a population pharmacokinetic (PK) model and simulate...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Al-Shaer, Mohammad H., Märtson, Anne-Grete, Alghamdi, Wael A., Alsultan, Abdullah, An, Guohua, Ahmed, Shahriar, Alkabab, Yosra, Banu, Sayera, Houpt, Eric R., Ashkin, David, Griffith, David E., Cegielski, J. Peter, Heysell, Scott K., Peloquin, Charles A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7449188/
https://ncbi.nlm.nih.gov/pubmed/32631828
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00713-20
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