Population Pharmacokinetics of Linezolid in Tuberculosis Patients: Dosing Regimen Simulation and Target Attainment Analysis

The prolonged treatment duration for multidrug-resistant tuberculosis (MDR-TB) makes linezolid dosing difficult because of adverse effects associated with long-term use. We sought to find the optimal dosing regimen for linezolid across different MIC values. Pharmacokinetic (PK) data from TB patients...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Alghamdi, Wael A., Al-Shaer, Mohammad H., An, Guohua, Alsultan, Abdullah, Kipiani, Maia, Barbakadze, Ketevan, Mikiashvili, Lali, Ashkin, David, Griffith, David E., Cegielski, J. Peter, Kempker, Russell R., Peloquin, Charles A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2020
Assuntos:
Clinical Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7508612/
https://ncbi.nlm.nih.gov/pubmed/32778547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01174-20
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