Cycloserine Population Pharmacokinetics and Pharmacodynamics in Patients with Tuberculosis

Limited pharmacokinetic/pharmacodynamic (PK/PD) data exist on cycloserine in tuberculosis (TB) patients. We pooled several studies into a large PK data set to estimate the population PK parameters for cycloserine in TB patients. We also performed simulations to provide insight into optimizing the do...

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Detalles Bibliográficos
Publicado en:Antimicrob Agents Chemother
Autores principales: Alghamdi, Wael A., Alsultan, Abdullah, Al-Shaer, Mohammad H., An, Guohua, Ahmed, Shahriar, Alkabab, Yosra, Banu, Sayera, Barbakadze, Ketevan, Houpt, Eric, Kipiani, Maia, Mikiashvili, Lali, Schmidt, Stephan, Heysell, Scott K., Kempker, Russell R., Cegielski, J. Peter, Peloquin, Charles A.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2019
Materias:
Clinical Therapeutics
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6496076/
https://ncbi.nlm.nih.gov/pubmed/30858211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00055-19
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