Ethionamide Population Pharmacokinetic Model and Target Attainment in Multidrug-Resistant Tuberculosis

Ethionamide (ETA), an isonicotinic acid derivative, is part of the multidrug-resistant tuberculosis (MDR-TB) regimen. The current guidelines have deprioritized ETA because it is potentially less effective than other agents. Our aim was to develop a population pharmacokinetic (PK) model and simulate...

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Vydáno v:Antimicrob Agents Chemother
Hlavní autoři: Al-Shaer, Mohammad H., Märtson, Anne-Grete, Alghamdi, Wael A., Alsultan, Abdullah, An, Guohua, Ahmed, Shahriar, Alkabab, Yosra, Banu, Sayera, Houpt, Eric R., Ashkin, David, Griffith, David E., Cegielski, J. Peter, Heysell, Scott K., Peloquin, Charles A.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2020
Témata:
Clinical Therapeutics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7449188/
https://ncbi.nlm.nih.gov/pubmed/32631828
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00713-20
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