Single-cell RNA-sequencing reveals distinct patterns of cell state heterogeneity in mouse models of breast cancer

Breast cancer stem cells (BCSCs) contribute to intra-tumoral heterogeneity and therapeutic resistance. However, the binary concept of universal BCSCs co-existing with bulk tumor cells is over-simplified. Through single-cell RNA-sequencing, we found that Neu, PyMT and BRCA1-null mammary tumors each c...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Yeo, Syn Kok, Zhu, Xiaoting, Okamoto, Takako, Hao, Mingang, Wang, Cailian, Lu, Peixin, Lu, Long Jason, Guan, Jun-Lin
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2020
Assuntos:
Cancer Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7447441/
https://ncbi.nlm.nih.gov/pubmed/32840210
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.58810
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