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Autophagy inhibition perturbs ERBB2 trafficking and abolishes tumorigenesis in ERBB2-driven breast cancer

Macroautophagy/autophagy modulation is increasingly recognized as a potential strategy for cancer therapy. Using a recently developed Rb1cc1 mutant knockin mice model, we have taken a rigorous genetic approach to assess the role of both its autophagy and non-canonical functions in an ERBB2-driven Br...

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Detalhes bibliográficos
Publicado no:Autophagy
Main Authors: Hao, Mingang, Yeo, Syn Kok, Guan, Jun-Lin
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8078671/
https://ncbi.nlm.nih.gov/pubmed/33757386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2021.1907168
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