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Reversible Formation of Alkyl Radicals at [Fe(4)S(4)] Clusters and Its Implications for Selectivity in Radical SAM Enzymes

All kingdoms of life use the transient 5′-deoxyadenosyl radical (5′-dAdo•) to initiate a wide range of difficult chemical reactions. Because of its high reactivity, the 5′-dAdo• must be generated in a controlled manner to abstract a specific H atom and avoid unproductive reactions. In radical S-aden...

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Publicado en:J Am Chem Soc
Autores principales: Brown, Alexandra C., Suess, Daniel L. M.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2020
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7447116/
https://ncbi.nlm.nih.gov/pubmed/32696642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.0c05590
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