Radiation causes tissue damage by dysregulating inflammasome–gasdermin D signaling in both host and transplanted cells

Radiotherapy is a commonly used conditioning regimen for bone marrow transplantation (BMT). Cytotoxicity limits the use of this life-saving therapy, but the underlying mechanisms remain poorly defined. Here, we use the syngeneic mouse BMT model to test the hypothesis that lethal radiation damages ti...

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Detalhes bibliográficos
Publicado no:PLoS Biol
Main Authors: Xiao, Jianqiu, Wang, Chun, Yao, Juo-Chin, Alippe, Yael, Yang, Tong, Kress, Dustin, Sun, Kai, Kostecki, Kourtney L., Monahan, Joseph B., Veis, Deborah J., Abu-Amer, Yousef, Link, Daniel C., Mbalaviele, Gabriel
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2020
Assuntos:
Short Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7446913/
https://ncbi.nlm.nih.gov/pubmed/32760056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.3000807
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