Gasdermin D mediates the pathogenesis of neonatal-onset multisystem inflammatory disease in mice

Mutated NLRP3 assembles a hyperactive inflammasome, which causes excessive secretion of interleukin (IL)-1β and IL-18 and, ultimately, a spectrum of autoinflammatory disorders known as cryopyrinopathies of which neonatal-onset multisystem inflammatory disease (NOMID) is the most severe phenotype. NO...

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Опубликовано в: :PLoS Biol
Главные авторы: Xiao, Jianqiu, Wang, Chun, Yao, Juo-Chin, Alippe, Yael, Xu, Canxin, Kress, Dustin, Civitelli, Roberto, Abu-Amer, Yousef, Kanneganti, Thirumala-Devi, Link, Daniel C., Mbalaviele, Gabriel
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2018
Предметы:
Short Reports
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6235378/
https://ncbi.nlm.nih.gov/pubmed/30388107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.3000047
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