Age and the association between apolipoprotein E genotype and Alzheimer disease: A cerebrospinal fluid biomarker–based case–control study

BACKGROUND: The ε4 allele of apolipoprotein E (APOE) gene and increasing age are two of the most important known risk factors for developing Alzheimer disease (AD). The diagnosis of AD based on clinical symptoms alone is known to have poor specificity; recently developed diagnostic criteria based on...

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Veröffentlicht in:PLoS Med
Hauptverfasser: Saddiki, Hana, Fayosse, Aurore, Cognat, Emmanuel, Sabia, Séverine, Engelborghs, Sebastiaan, Wallon, David, Alexopoulos, Panagiotis, Blennow, Kaj, Zetterberg, Henrik, Parnetti, Lucilla, Zerr, Inga, Hermann, Peter, Gabelle, Audrey, Boada, Mercè, Orellana, Adelina, de Rojas, Itziar, Lilamand, Matthieu, Bjerke, Maria, Van Broeckhoven, Christine, Farotti, Lucia, Salvadori, Nicola, Diehl-Schmid, Janine, Grimmer, Timo, Hourregue, Claire, Dugravot, Aline, Nicolas, Gaël, Laplanche, Jean-Louis, Lehmann, Sylvain, Bouaziz-Amar, Elodie, Hugon, Jacques, Tzourio, Christophe, Singh-Manoux, Archana, Paquet, Claire, Dumurgier, Julien
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2020
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7446786/
https://ncbi.nlm.nih.gov/pubmed/32817639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pmed.1003289
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