Age and the association between apolipoprotein E genotype and Alzheimer disease: A cerebrospinal fluid biomarker–based case–control study

BACKGROUND: The ε4 allele of apolipoprotein E (APOE) gene and increasing age are two of the most important known risk factors for developing Alzheimer disease (AD). The diagnosis of AD based on clinical symptoms alone is known to have poor specificity; recently developed diagnostic criteria based on...

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Publicat a:PLoS Med
Autors principals: Saddiki, Hana, Fayosse, Aurore, Cognat, Emmanuel, Sabia, Séverine, Engelborghs, Sebastiaan, Wallon, David, Alexopoulos, Panagiotis, Blennow, Kaj, Zetterberg, Henrik, Parnetti, Lucilla, Zerr, Inga, Hermann, Peter, Gabelle, Audrey, Boada, Mercè, Orellana, Adelina, de Rojas, Itziar, Lilamand, Matthieu, Bjerke, Maria, Van Broeckhoven, Christine, Farotti, Lucia, Salvadori, Nicola, Diehl-Schmid, Janine, Grimmer, Timo, Hourregue, Claire, Dugravot, Aline, Nicolas, Gaël, Laplanche, Jean-Louis, Lehmann, Sylvain, Bouaziz-Amar, Elodie, Hugon, Jacques, Tzourio, Christophe, Singh-Manoux, Archana, Paquet, Claire, Dumurgier, Julien
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2020
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7446786/
https://ncbi.nlm.nih.gov/pubmed/32817639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pmed.1003289
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