Age and the association between apolipoprotein E genotype and Alzheimer disease: A cerebrospinal fluid biomarker–based case–control study

BACKGROUND: The ε4 allele of apolipoprotein E (APOE) gene and increasing age are two of the most important known risk factors for developing Alzheimer disease (AD). The diagnosis of AD based on clinical symptoms alone is known to have poor specificity; recently developed diagnostic criteria based on...

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Detalhes bibliográficos
Publicado no:PLoS Med
Main Authors: Saddiki, Hana, Fayosse, Aurore, Cognat, Emmanuel, Sabia, Séverine, Engelborghs, Sebastiaan, Wallon, David, Alexopoulos, Panagiotis, Blennow, Kaj, Zetterberg, Henrik, Parnetti, Lucilla, Zerr, Inga, Hermann, Peter, Gabelle, Audrey, Boada, Mercè, Orellana, Adelina, de Rojas, Itziar, Lilamand, Matthieu, Bjerke, Maria, Van Broeckhoven, Christine, Farotti, Lucia, Salvadori, Nicola, Diehl-Schmid, Janine, Grimmer, Timo, Hourregue, Claire, Dugravot, Aline, Nicolas, Gaël, Laplanche, Jean-Louis, Lehmann, Sylvain, Bouaziz-Amar, Elodie, Hugon, Jacques, Tzourio, Christophe, Singh-Manoux, Archana, Paquet, Claire, Dumurgier, Julien
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7446786/
https://ncbi.nlm.nih.gov/pubmed/32817639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pmed.1003289
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