Outcomes of BRAF V600E Pediatric Gliomas Treated With Targeted BRAF Inhibition

PURPOSE: Children with pediatric gliomas harboring a BRAF V600E mutation have poor outcomes with current chemoradiotherapy strategies. Our aim was to study the role of targeted BRAF inhibition in these tumors. PATIENTS AND METHODS: We collected clinical, imaging, molecular, and outcome information f...

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Pubblicato in:JCO Precis Oncol
Autori principali: Nobre, Liana, Zapotocky, Michal, Ramaswamy, Vijay, Ryall, Scott, Bennett, Julie, Alderete, Daniel, Balaguer Guill, Julia, Baroni, Lorena, Bartels, Ute, Bavle, Abhishek, Bornhorst, Miriam, Boue, Daniel R., Canete, Adela, Chintagumpala, Murali, Coven, Scott L., Cruz, Ofelia, Dahiya, Sonika, Dirks, Peter, Dunkel, Ira J., Eisenstat, David, Faure Conter, Cecile, Finch, Elizabeth, Finlay, Jonathan L., Frappaz, Didier, Garre, Maria Luisa, Gauvain, Karen, Bechensteen, Anne Grete, Hansford, Jordan R., Harting, Inga, Hauser, Peter, Hazrati, Lili-Naz, Huang, Annie, Injac, Sarah G., Iurilli, Valentina, Karajannis, Matthias, Kaur, Gurcharanjeet, Kyncl, Martin, Krskova, Lenka, Laperriere, Normand, Larouche, Valerie, Lassaletta, Alvaro, Leary, Sarah, Lin, Frank, Mascelli, Samantha, McKeown, Tara, Milde, Till, Morales La Madrid, Andres, Morana, Giovanni, Morse, Helena, Mushtaq, Naureen, Osorio, Diana S., Packer, Roger, Pavelka, Zdenek, Quiroga-Cantero, Eduardo, Rutka, James, Sabel, Magnus, Salgado, Duarte, Solano, Palma, Sterba, Jaroslav, Su, Jack, Sumerauer, David, Taylor, Michael D., Toledano, Helen, Tsang, Derek S., Valente Fernandes, Mariana, van Landeghem, Frank, van Tilburg, Cornelis M., Wilson, Bev, Witt, Olaf, Zamecnik, Josef, Bouffet, Eric, Hawkins, Cynthia, Tabori, Uri
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Clinical Oncology 2020
Soggetti:
Original Reports
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7446502/
https://ncbi.nlm.nih.gov/pubmed/32923898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/PO.19.00298
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