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Lysosome Positioning Influences mTORC2 and AKT Signaling

Growth factor signaling is initiated at the plasma membrane and propagated through the cytoplasm for eventual relay to intracellular organelles such as lysosomes. The serine/threonine kinase mTOR participates in growth factor signaling as a component of two complexes, mTORC1 and mTORC2. mTORC1 assoc...

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Publicado en:Mol Cell
Autores principales: Jia, Rui, Bonifacino, Juan S.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2019
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7446307/
https://ncbi.nlm.nih.gov/pubmed/31130364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2019.05.009
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