Lsh/HELLS is required for B lymphocyte development and immunoglobulin class switch recombination

Mutation of HELLS (Helicase, Lymphoid-Specific)/Lsh in human DNA causes a severe immunodeficiency syndrome, but the nature of the defect remains unknown. We assessed here the role of Lsh in hematopoiesis using conditional Lsh knockout mice with expression of Mx1 or Vav Cre-recombinase. Bone marrow t...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: He, Yafeng, Ren, Jianke, Xu, Xiaoping, Ni, Kai, Schwader, Andrew, Finney, Richard, Wang, Can, Sun, Lei, Klarmann, Kimberly, Keller, Jonathan, Tubbs, Anthony, Nussenzweig, Andre, Muegge, Kathrin
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2020
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7443918/
https://ncbi.nlm.nih.gov/pubmed/32727902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2004112117
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