LSH mediates gene repression through macroH2A deposition

The human Immunodeficiency Centromeric Instability Facial Anomalies (ICF) 4 syndrome is a severe disease with increased mortality caused by mutation in the LSH gene. Although LSH belongs to a family of chromatin remodeling proteins, it remains unknown how LSH mediates its function on chromatin in vi...

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Publicat a:Nat Commun
Autors principals: Ni, Kai, Ren, Jianke, Xu, Xiaoping, He, Yafeng, Finney, Richard, Braun, Simon M. G., Hathaway, Nathaniel A., Crabtree, Gerald R., Muegge, Kathrin
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7648012/
https://ncbi.nlm.nih.gov/pubmed/33159050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-19159-0
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