Lsh/HELLS is required for B lymphocyte development and immunoglobulin class switch recombination

Mutation of HELLS (Helicase, Lymphoid-Specific)/Lsh in human DNA causes a severe immunodeficiency syndrome, but the nature of the defect remains unknown. We assessed here the role of Lsh in hematopoiesis using conditional Lsh knockout mice with expression of Mx1 or Vav Cre-recombinase. Bone marrow t...

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Detaylı Bibliyografya
Yayımlandı:Proc Natl Acad Sci U S A
Asıl Yazarlar: He, Yafeng, Ren, Jianke, Xu, Xiaoping, Ni, Kai, Schwader, Andrew, Finney, Richard, Wang, Can, Sun, Lei, Klarmann, Kimberly, Keller, Jonathan, Tubbs, Anthony, Nussenzweig, Andre, Muegge, Kathrin
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2020
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7443918/
https://ncbi.nlm.nih.gov/pubmed/32727902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2004112117
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