Necroptosis-based CRISPR knockout screen reveals Neuropilin-1 as a critical host factor for early stages of murine cytomegalovirus infection

Herpesviruses are ubiquitous human pathogens that cause a wide range of health complications. Currently, there is an incomplete understanding of cellular factors that contribute to herpesvirus infection. Here, we report an antiviral necroptosis-based genetic screen to identify novel host cell factor...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Lane, Rebecca K., Guo, Hongyan, Fisher, Amanda D., Diep, Jonathan, Lai, Zhao, Chen, Yidong, Upton, Jason W., Carette, Jan, Mocarski, Edward S., Kaiser, William J.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2020
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7443917/
https://ncbi.nlm.nih.gov/pubmed/32747526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1921315117
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