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A folding reaction at the C-terminal domain drives temperature sensing in TRPM8 channels
In mammals, temperature-sensitive TRP channels make membrane conductance of cells extremely temperature dependent, allowing the detection of temperature ranging from noxious cold to noxious heat. We progressively deleted the distal carboxyl terminus domain (CTD) of the cold-activated melastatin rece...
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| Veröffentlicht in: | Proc Natl Acad Sci U S A |
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| Hauptverfasser: | , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2020
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7443914/ https://ncbi.nlm.nih.gov/pubmed/32747539 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2004303117 |
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