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A folding reaction at the C-terminal domain drives temperature sensing in TRPM8 channels
In mammals, temperature-sensitive TRP channels make membrane conductance of cells extremely temperature dependent, allowing the detection of temperature ranging from noxious cold to noxious heat. We progressively deleted the distal carboxyl terminus domain (CTD) of the cold-activated melastatin rece...
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| Publicado no: | Proc Natl Acad Sci U S A |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7443914/ https://ncbi.nlm.nih.gov/pubmed/32747539 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2004303117 |
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