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Lysines in the lyase active site of DNA polymerase β destabilize nonspecific DNA binding, facilitating searching and DNA gap recognition

DNA polymerase (pol) β catalyzes two reactions at DNA gaps generated during base excision repair, gap-filling DNA synthesis and lyase-dependent 5´-end deoxyribose phosphate removal. The lyase domain of pol β has been proposed to function in DNA gap recognition and to facilitate DNA scanning during s...

詳細記述

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書誌詳細
出版年:J Biol Chem
主要な著者: Howard, Michael J., Horton, Julie K., Zhao, Ming-Lang, Wilson, Samuel H.
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Biochemistry and Molecular Biology 2020
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7443498/
https://ncbi.nlm.nih.gov/pubmed/32647014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.013547
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