Protein phosphatase 4 promotes Hedgehog signaling through dephosphorylation of Suppressor of fused

Reversible phosphorylation of Suppressor of fused (Sufu) is essential for Sonic Hedgehog (Shh) signal transduction. Sufu is stabilized under dual phosphorylation of protein kinase A (PKA) and glycogen synthase kinase 3β (GSK3β). Its phosphorylation is reduced with the activation of Shh signaling. Ho...

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Bibliographic Details
Published in:Cell Death Dis
Main Authors: Liao, Hengqing, Cai, Jing, Liu, Chen, Shen, Longyan, Pu, Xiaohong, Yao, Yixing, Han, Bo’ang, Yu, Tingting, Cheng, Steven Y., Yue, Shen
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7442787/
https://ncbi.nlm.nih.gov/pubmed/32826873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-02843-w
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