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Protein phosphatase 4 promotes Hedgehog signaling through dephosphorylation of Suppressor of fused

Reversible phosphorylation of Suppressor of fused (Sufu) is essential for Sonic Hedgehog (Shh) signal transduction. Sufu is stabilized under dual phosphorylation of protein kinase A (PKA) and glycogen synthase kinase 3β (GSK3β). Its phosphorylation is reduced with the activation of Shh signaling. Ho...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Liao, Hengqing, Cai, Jing, Liu, Chen, Shen, Longyan, Pu, Xiaohong, Yao, Yixing, Han, Bo’ang, Yu, Tingting, Cheng, Steven Y., Yue, Shen
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7442787/
https://ncbi.nlm.nih.gov/pubmed/32826873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-02843-w
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