Targeting MCL-1 in Hematologic Malignancies: Rationale and Progress

Myeloid cell leukemia sequence 1 (MCL-1) is an antiapoptotic protein that plays a key role in promoting cell survival in multiple myeloma (MM), acute myeloid leukemia (AML), and non-Hodgkin lymphoma (NHL). Overexpression of MCL-1 is associated with treatment resistance and poor prognosis; thus, MCL-...

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Publicado no:Blood Rev
Main Authors: Wei, Andrew H., Roberts, Andrew W., Spencer, Andrew, Rosenberg, Aaron Seth, Siegel, David, Walter, Roland B., Caenepeel, Sean, Hughes, Paul, McIver, Zach, Mezzi, Khalid, Morrow, Phuong Khanh, Stein, Anthony
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7442684/
https://ncbi.nlm.nih.gov/pubmed/32204955
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.blre.2020.100672
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