Mechanistic rationale for MCL1 inhibition during androgen deprivation therapy

Androgen deprivation therapy induces apoptosis or cell cycle arrest in prostate cancer (PCa) cells. Here we set out to analyze whether MCL1, a known mediator of chemotherapy resistance regulates the cellular response to androgen withdrawal. Analysis of MCL1 protein and mRNA expression in PCa tissue...

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發表在:Oncotarget
Main Authors: Santer, Frédéric R., Erb, Holger H. H., Oh, Su Jung, Handle, Florian, Feiersinger, Gertrud E., Luef, Birgit, Bu, Huajie, Schäfer, Georg, Ploner, Christian, Egger, Martina, Rane, Jayant K., Maitland, Norman J., Klocker, Helmut, Eder, Iris E., Culig, Zoran
格式: Artigo
語言:Inglês
出版: Impact Journals LLC 2015
主題:
Research Paper
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4467425/
https://ncbi.nlm.nih.gov/pubmed/25749045
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