Mechanistic rationale for MCL1 inhibition during androgen deprivation therapy

Androgen deprivation therapy induces apoptosis or cell cycle arrest in prostate cancer (PCa) cells. Here we set out to analyze whether MCL1, a known mediator of chemotherapy resistance regulates the cellular response to androgen withdrawal. Analysis of MCL1 protein and mRNA expression in PCa tissue...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Santer, Frédéric R., Erb, Holger H. H., Oh, Su Jung, Handle, Florian, Feiersinger, Gertrud E., Luef, Birgit, Bu, Huajie, Schäfer, Georg, Ploner, Christian, Egger, Martina, Rane, Jayant K., Maitland, Norman J., Klocker, Helmut, Eder, Iris E., Culig, Zoran
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4467425/
https://ncbi.nlm.nih.gov/pubmed/25749045
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