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NRF2 mediates γ-globin gene regulation through epigenetic modifications in a β-YAC transgenic mouse model
NRF2 is the master regulator for the cellular oxidative stress response and regulates γ-globin gene expression in human erythroid progenitors and sickle cell disease mice. To explore NRF2 function, we established a human β-globin locus yeast artificial chromosome transgenic/NRF2 knockout (β-YAC/NRF2...
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| Publicado no: | Exp Biol Med (Maywood) |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
SAGE Publications
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7441346/ https://ncbi.nlm.nih.gov/pubmed/32715783 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1535370220945305 |
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