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Cryo-EM structure of the lysosomal chloride-proton exchanger CLC-7 in complex with OSTM1
The chloride-proton exchanger CLC-7 plays critical roles in lysosomal homeostasis and bone regeneration and its mutation can lead to osteopetrosis, lysosomal storage disease and neurological disorders. In lysosomes and the ruffled border of osteoclasts, CLC-7 requires a β-subunit, OSTM1, for stabili...
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| Publicado no: | eLife |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
eLife Sciences Publications, Ltd
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7440919/ https://ncbi.nlm.nih.gov/pubmed/32749217 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.59555 |
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