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Uncoupling endosomal CLC chloride/proton exchange causes severe neurodegeneration
CLC chloride/proton exchangers may support acidification of endolysosomes and raise their luminal Cl(−) concentration. Disruption of endosomal ClC‐3 causes severe neurodegeneration. To assess the importance of ClC‐3 Cl(−)/H(+) exchange, we now generate Clcn3 (unc/unc) mice in which ClC‐3 is converte...
Gardado en:
| Publicado en: | EMBO J |
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| Main Authors: | , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
John Wiley and Sons Inc.
2020
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7196918/ https://ncbi.nlm.nih.gov/pubmed/32118314 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2019103358 |
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