Uncoupling endosomal CLC chloride/proton exchange causes severe neurodegeneration

CLC chloride/proton exchangers may support acidification of endolysosomes and raise their luminal Cl(−) concentration. Disruption of endosomal ClC‐3 causes severe neurodegeneration. To assess the importance of ClC‐3 Cl(−)/H(+) exchange, we now generate Clcn3 (unc/unc) mice in which ClC‐3 is converte...

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Pubblicato in:EMBO J
Autori principali: Weinert, Stefanie, Gimber, Niclas, Deuschel, Dorothea, Stuhlmann, Till, Puchkov, Dmytro, Farsi, Zohreh, Ludwig, Carmen F, Novarino, Gaia, López‐Cayuqueo, Karen I, Planells‐Cases, Rosa, Jentsch, Thomas J
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2020
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Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7196918/
https://ncbi.nlm.nih.gov/pubmed/32118314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2019103358
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