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LRRC8/VRAC anion channels enhance β-cell glucose sensing and insulin secretion

Glucose homeostasis depends critically on insulin that is secreted by pancreatic β-cells. Serum glucose, which is directly sensed by β-cells, stimulates depolarization- and Ca(2+)-dependent exocytosis of insulin granules. Here we show that pancreatic islets prominently express LRRC8A and LRRC8D, sub...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Stuhlmann, Till, Planells-Cases, Rosa, Jentsch, Thomas J.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5958052/
https://ncbi.nlm.nih.gov/pubmed/29773801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-04353-y
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