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LRRC8/VRAC anion channels enhance β-cell glucose sensing and insulin secretion
Glucose homeostasis depends critically on insulin that is secreted by pancreatic β-cells. Serum glucose, which is directly sensed by β-cells, stimulates depolarization- and Ca(2+)-dependent exocytosis of insulin granules. Here we show that pancreatic islets prominently express LRRC8A and LRRC8D, sub...
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| I publikationen: | Nat Commun |
|---|---|
| Huvudupphovsmän: | , , |
| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
Nature Publishing Group UK
2018
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5958052/ https://ncbi.nlm.nih.gov/pubmed/29773801 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-04353-y |
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