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Common Gating of Both CLC Transporter Subunits Underlies Voltage-dependent Activation of the 2Cl(−)/1H(+) Exchanger ClC-7/Ostm1

CLC anion transporters form dimers that function either as Cl(−) channels or as electrogenic Cl(−)/H(+) exchangers. CLC channels display two different types of “gates,” “protopore” gates that open and close the two pores of a CLC dimer independently of each other and common gates that act on both po...

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Autors principals: Ludwig, Carmen F., Ullrich, Florian, Leisle, Lilia, Stauber, Tobias, Jentsch, Thomas J.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2013
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3789960/
https://ncbi.nlm.nih.gov/pubmed/23983121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.509364
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