Divergent Cl(-) and H(+) pathways underlie transport coupling and gating in CLC exchangers and channels

The CLC family comprises H(+)-coupled exchangers and Cl(-) channels, and mutations causing their dysfunction lead to genetic disorders. The CLC exchangers, unlike canonical 'ping-pong' antiporters, simultaneously bind and translocate substrates through partially congruent pathways. How ion...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Leisle, Lilia, Xu, Yanyan, Fortea, Eva, Lee, Sangyun, Galpin, Jason D, Vien, Malvin, Ahern, Christopher A, Accardi, Alessio, Bernèche, Simon
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2020
Assuntos:
Biochemistry and Chemical Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7274781/
https://ncbi.nlm.nih.gov/pubmed/32343228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.51224
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