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Proton block of the CLC-5 Cl(−)/H(+) exchanger

CLC-5 is a H(+)/Cl(−) exchanger that is expressed primarily in endosomes but can traffic to the plasma membrane in overexpression systems. Mutations altering the expression or function of CLC-5 lead to Dent’s disease. Currents mediated by this transporter show extreme outward rectification and are i...

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Detalhes bibliográficos
Main Authors: Picollo, Alessandra, Malvezzi, Mattia, Accardi, Alessio
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2888053/
https://ncbi.nlm.nih.gov/pubmed/20513761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201010428
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