A social encounter drives gene expression changes linked to neuronal function, brain development, and related disorders in mice expressing the serotonin transporter Ala56 variant.

Multiple lines of evidence implicate the serotonin (5-HT) system in social function, including biomarker findings in autism spectrum disorder. In mice, knock-in of a rare Gly56Ala substitution in the serotonin transporter (SERT) causes elevated whole blood 5-HT levels, increased 5-HT clearance in th...

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Pubblicato in:Neurosci Lett
Autori principali: O’Reilly, Kally C., Anacker, Allison M. J., Rogers, Tiffany D., Forsberg, C. Gunnar, Wang, Jing, Zhang, Bing, Blakely, Randy D., Veenstra-VanderWeele, Jeremy
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7440397/
https://ncbi.nlm.nih.gov/pubmed/32437898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neulet.2020.135027
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