Epigenetically heterogeneous tumor cells direct collective invasion through filopodia-driven fibronectin micropatterning

Tumor heterogeneity drives disease progression, treatment resistance, and patient relapse, yet remains largely underexplored in invasion and metastasis. Here, we investigated heterogeneity within collective cancer invasion by integrating DNA methylation and gene expression analysis in rare purified...

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Enregistré dans:
Détails bibliographiques
Publié dans:Sci Adv
Auteurs principaux: Summerbell, Emily R., Mouw, Janna K., Bell, Joshua S. K., Knippler, Christina M., Pedro, Brian, Arnst, Jamie L., Khatib, Tala O., Commander, Rachel, Barwick, Benjamin G., Konen, Jessica, Dwivedi, Bhakti, Seby, Sandra, Kowalski, Jeanne, Vertino, Paula M., Marcus, Adam I.
Format: Artigo
Langue:Inglês
Publié: American Association for the Advancement of Science 2020
Sujets:
Research Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7439406/
https://ncbi.nlm.nih.gov/pubmed/32832657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aaz6197
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