Epigenetically heterogeneous tumor cells direct collective invasion through filopodia-driven fibronectin micropatterning

Tumor heterogeneity drives disease progression, treatment resistance, and patient relapse, yet remains largely underexplored in invasion and metastasis. Here, we investigated heterogeneity within collective cancer invasion by integrating DNA methylation and gene expression analysis in rare purified...

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Dades bibliogràfiques
Publicat a:Sci Adv
Autors principals: Summerbell, Emily R., Mouw, Janna K., Bell, Joshua S. K., Knippler, Christina M., Pedro, Brian, Arnst, Jamie L., Khatib, Tala O., Commander, Rachel, Barwick, Benjamin G., Konen, Jessica, Dwivedi, Bhakti, Seby, Sandra, Kowalski, Jeanne, Vertino, Paula M., Marcus, Adam I.
Format: Artigo
Idioma:Inglês
Publicat: American Association for the Advancement of Science 2020
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7439406/
https://ncbi.nlm.nih.gov/pubmed/32832657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aaz6197
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