Epigenetically heterogeneous tumor cells direct collective invasion through filopodia-driven fibronectin micropatterning

Tumor heterogeneity drives disease progression, treatment resistance, and patient relapse, yet remains largely underexplored in invasion and metastasis. Here, we investigated heterogeneity within collective cancer invasion by integrating DNA methylation and gene expression analysis in rare purified...

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Vydáno v:Sci Adv
Hlavní autoři: Summerbell, Emily R., Mouw, Janna K., Bell, Joshua S. K., Knippler, Christina M., Pedro, Brian, Arnst, Jamie L., Khatib, Tala O., Commander, Rachel, Barwick, Benjamin G., Konen, Jessica, Dwivedi, Bhakti, Seby, Sandra, Kowalski, Jeanne, Vertino, Paula M., Marcus, Adam I.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Association for the Advancement of Science 2020
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7439406/
https://ncbi.nlm.nih.gov/pubmed/32832657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aaz6197
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