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Epigenetically heterogeneous tumor cells direct collective invasion through filopodia-driven fibronectin micropatterning

Tumor heterogeneity drives disease progression, treatment resistance, and patient relapse, yet remains largely underexplored in invasion and metastasis. Here, we investigated heterogeneity within collective cancer invasion by integrating DNA methylation and gene expression analysis in rare purified...

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書誌詳細
出版年:Sci Adv
主要な著者: Summerbell, Emily R., Mouw, Janna K., Bell, Joshua S. K., Knippler, Christina M., Pedro, Brian, Arnst, Jamie L., Khatib, Tala O., Commander, Rachel, Barwick, Benjamin G., Konen, Jessica, Dwivedi, Bhakti, Seby, Sandra, Kowalski, Jeanne, Vertino, Paula M., Marcus, Adam I.
フォーマット: Artigo
言語:Inglês
出版事項: American Association for the Advancement of Science 2020
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7439406/
https://ncbi.nlm.nih.gov/pubmed/32832657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aaz6197
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