Factors affecting the persistence of drug-induced reprogramming of the cancer methylome

Aberrant DNA methylation is a critical feature of cancer. Epigenetic therapy seeks to reverse these changes to restore normal gene expression. DNA demethylating agents, including 5-aza-2′-deoxycytidine (DAC), are currently used to treat certain leukemias, and can sensitize solid tumors to chemothera...

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Detalhes bibliográficos
Publicado no:Epigenetics
Main Authors: Bell, Joshua S. K., Kagey, Jacob D., Barwick, Benjamin G., Dwivedi, Bhakti, McCabe, Michael T., Kowalski, Jeanne, Vertino, Paula M.
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4889262/
https://ncbi.nlm.nih.gov/pubmed/27082926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15592294.2016.1158364
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