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Factors affecting the persistence of drug-induced reprogramming of the cancer methylome
Aberrant DNA methylation is a critical feature of cancer. Epigenetic therapy seeks to reverse these changes to restore normal gene expression. DNA demethylating agents, including 5-aza-2′-deoxycytidine (DAC), are currently used to treat certain leukemias, and can sensitize solid tumors to chemothera...
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| Опубликовано в: : | Epigenetics |
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| Главные авторы: | , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Taylor & Francis
2016
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4889262/ https://ncbi.nlm.nih.gov/pubmed/27082926 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15592294.2016.1158364 |
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