mTORC1-IRE1α pathway activation contributes to palmitate-elicited triglyceride secretion and cell death in hepatocytes

Lipotoxicity, defined as the cell death and/or cellular dysfunction induced by ectopic lipid deposition, plays a pathological role in the development of many metabolic diseases. Although endoplasmic reticulum stress is a well-documented mechanism behind, how endoplasmic reticulum stress is initiated...

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Bibliografiska uppgifter
I publikationen:Exp Biol Med (Maywood)
Huvudupphovsmän: Wang, Jun, Chen, Yingli, Song, Qing, Griffiths, Alexandra, Song, Zhenyuan
Materialtyp: Artigo
Språk:Inglês
Publicerad: SAGE Publications 2020
Ämnen:
Original Research
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7437378/
https://ncbi.nlm.nih.gov/pubmed/32436749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1535370220928276
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