Inositol-requiring enzyme 1α links palmitate-induced mTOR activation and lipotoxicity in hepatocytes

Hepatic lipotoxicity, hepatocyte dysfunction/cell death induced by saturated fatty acids (SFA), plays a central role in the pathogenesis of nonalcoholic fatty liver disease (NAFLD); however, the underlying mechanisms remain unclear. Palmitate is the most abundant SFA in the circulation. In this stud...

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Veröffentlicht in:Am J Physiol Cell Physiol
Hauptverfasser: Chen, Yingli, Griffiths, Alexandra, Wang, Jun, Zhang, Tingting, Song, Qing, Song, Zhenyuan
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Physiological Society 2020
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7792676/
https://ncbi.nlm.nih.gov/pubmed/33052067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00165.2020
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